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Disruptions in circadian rhythms can adversely affect sleep quality and lead to imbalances in gut microbiota, resulting in alterations to the community structure, ecological parameters of the microbial ecosystem, and the inflammatory state of the body [45, 214,215,216,217,218,219,220,221]

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations TMAU, trimethylaminuria

Trimethylamine N-oxide (TMAO) and N,N,N-trimethylglycine (betaine) are methylamine osmolytes that have been extensively studied for their diverse roles in humans and have demonstrated opposing relations with human health

We thank Qin Deng and Guocan Zheng in Analytic and Testing Center of Chongqing University for use of the facility and technical support for confocal and GCMS/MS analysis, ShanghaiTech School of Life Science and Technology Core facility, and Ying Han for their assistance with sphingolipid profiling and quantification, and Yu Kong and Lijun Pan (Electron Microscopy Facilities of Center for Excellence in Brain Science and Technology, CAS) for assistance with EM sample preparation and EM image analysis

reference number 20-1122)