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also showed significant increases in serum concentrations of asymmetric dimethylarginine (ADMA), enhanced inhibition of NOS, enhanced catabolism of Arg, increased levels of ornithine (Orn) and proline (Pro), and decreased Arg/Orn ratio in patients with asthma and obstructive sleep apnea (OSA)

Glutathione, an antioxidant, reduces oxidative stress by neutralizing ROS in the large intestine 28

Since CD9 is increased in the plasma membrane of senescent cells [146], CD9 antibody-conjugated nanoparticles are developed to selectively deliver drugs to senescent cells and suppress their phenotype in HDFs [147, 148]

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