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Histol Histopathol (2005) 20:20519

Desai RJ et al, 2012

Participants started at 2mg and increased to 4mg, then 6mg, then 9mg, and finally 12mg for the highest dose group

These studies also showed that large amounts of NO produced by ECs diffuse into VSMCs, where NO is essential for regulating vascular contraction and relaxation (63-65)