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*Correspondence: Richard Eugene Frye, Arkansas Childrens Hospital Research Institute, Slot 512-41B, 13 Childrens Way, Little Rock, AR 72202, USA e-mail: [email protected] This article was submitted to Child and Neurodevelopmental Psychiatry, a section of the journal Frontiers in Pediatrics

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dietary uptake Carnitine shuttle system Acylcarnitines and their roles Carnitine and microbiota Carnitine as a food supplement Clinical applications of carnitine and its metabolites Rare diseases History & Evolution 1905: discovery | 1927: structure elucidation Discovered in meat extracts, carnitine takes its name from the latin carnis meaning meat or flesh

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