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[51] Cu + coming from CCS D1 or an alternative cuprochaperone, such as glutathione,[ 49a , 55 ] can now bind at the entry site, and either O 2 . or H 2 O 2 can diffuse toward the electropositive cavity harboring SOD1 Cys146

Van Remmen H, Ikeno Y, Hamilton M et al (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging

A Phase 1 Ascending Dose Trial of Safety and Tolerability of Toca 511, a Retroviral Replicating Vector, Administered to Subjects at the Time of Resection for Recurrent High Grade Glioma & Followed by Treatment With Toca FC, Extended-Release 5-FC

To further assess efficacy in an external injury context we employed a standardised mouse tail bleeding assay 47

Distinctive properties of metastasis-initiating cells