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Description

Pep4 is a selected fragment of SLPI (Secretory Leucocyte Protease Inhibitor), whereas Pep4M is a modified form in which the highly reactive cysteine residues were replaced with less reactive methionine residues

The shared pathological mechanisms discussed below are graphically summarized in Figure 1, and the corresponding molecular targets and druggable nodes are illustrated in Figure 2

PLoS Negl Trop Dis 13:e0007186

Zhou J, Yang Y, Xie Z, Lu D, Huang J, Lan L et al (2024) Dysbiosis of gut microbiota and metabolites during AIDS: implications for CD4 + T cell reduction and immune activation