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When ethanol is metabolized in the liver, it undergoes a series of enzymatic reactions primarily mediated by alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH)

Similarly, in another study, 34% of patients with vitiligo had a history of thyroid disease (Yaghoobi et al., 2011)

In these reactions, -KG is oxidized to succinate, and increasing levels of succinate can suppress the progression of -KG-dependent histone or DNA demethylase reactions 98

doi: 10.3390/ijms22041509 69 TuomilehtoJLindstrmJErikssonJGValleTTHmlinenHIlanne-ParikkaPet al

Aging 9, 2489.CrossRefGoogle ScholarPubMed Cuanalo-Contreras, K, Mukherjee, A & Soto, C (2013) Role of protein misfolding and proteostasis deficiency in protein misfolding diseases and aging