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While the Akt/eNOS, NOX and Nrf2 pathways have been widely studied in the literature, it has been shown that phenolic compounds can modulate various cellular functions indirectly related to the redox balance regulation, such as inflammation or endothelial dysfunction (Reference Ruskovska, Maksimova and Milenkovic71)

The protein level of significantly increased p16 was confirmed in keloid lesions and fibroblasts based on western blot analysis ( p = 0.0007, p = 0.03

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Therefore, further research on these compounds, including their isolation, structural elucidation, and characterization, is needed to evaluate their efficacy and safety