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With consistent topical treatments, oral antibiotics if needed, and hormone dosage adjustments, testosterone-related acne can be effectively managed in most patients

doi:10.1016/j.anai.2013.09.016

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Additionally, aggregate amounts of demanded overpayment determinations, such as extrapolated overpayment demands, may be used to identify the amount of improper payments for a large set of claims for a particular provider or supplier and a certain time period, since error rates are extrapolated and applied to a universe of claims rather than individual claims

In addition to these direct genomic mechanisms, some steroid hormone receptors (e.g., estrogen receptors and the glucocorticoid receptor) can indirectly regulate gene expression at distinct promoters by tethering to other transcription factors (e.g., AP-1 and NF-B) (14, 15)