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It was found that RK1 had an inhibitory effect on liver cancer cells, simultaneously reducing GSH levels while raising MDA and iron levels

The endothelial cells are tightly connected by intracellular junctions that play a crucial role in maintaining the highly selective permeability of the BBB, allowing it to regulate the movement of ions, molecules, and cells between the blood and the neural tissue (84, 85)

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Doseinjury relationship: When NAPQI production exceeds glutathione supplythrough high single doses, high cumulative daily doses, or impaired conjugation/low GSHcentrilobular hepatic necrosis can occur