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10.1016/j.bbcan.2020.188338 27 ForsterF.SchullerJ

aureus, and B

At 0 C., to a stirred solution of 3-bromo-5-(difluoromethoxy)picolinaldehyde (1.14 g, 4.5 mmol) and DCM (9 mL) was added (diethylamino)sulfur trifluoride (2.4 mL, 18.1 mmol)

The mass ratio of 10/1(PEPS to deucravacitinib) was ultimately selected on the basis of the higher drug encapsulation efficiency (~45.76%) and drug loading rate (~4.16%) ( Figure 2A ), as determined by HPLC