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If one were to extrapolate from existing human trials: Dose: 0.51 mg per day Route: Sublingual or subcutaneous Duration: Up to 20 days (as used in circadian gene studies) Yet these regimens should not be considered prescriptive or approved protocols

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In some embodiments, the lipid-based drug delivery formulation or composition comprises a water-soluble preservative wherein the preservative is a benzethonium salt (e.g., benzethonium chloride), benzoic acid, and/or a benzylkonium salt (e.g., benzylkonium chloride)

10.1021/acsami.5b03668 123 ZhangZ.GuanJ.JiangZ.YangY.LiuJ.HuaW.et al (2019)