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For example, in hepatocellular carcinoma (HCC), ferroptosis serves as a tumor-suppressive mechanism in early stages but becomes dysregulated in advanced disease, suggesting that dynamic modulation may be necessary during different phases of neurodegeneration

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10.1146/annurev-biochem-040320-104628 Summary Keywords cadmium, mercury, nickel, manganese, element-specific detection, separation mechanism, mechanism of chronic toxicity Citation Gailer J (2026) Tailoring LC approaches to address the chemical biology of toxic metals in humans

Food allergy is thought to be a potential underlying mechanism

Administration:Oral gavage (p.o.), drinking water Result:Showed a faster blood flow recovery of the flap, an improved viability, reduced ROS production, increased NO level and iNOS expression (In the skin flap model)