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Stimulation of phagocytes triggers migration of cytosolic components towards the internal compartment of plasma membrane, forming an active enzyme complex with NADPH oxidase activity

doi: 10.1016/S0046-8177(03)00367-8 79 NichollsJMPoonLLLeeKCNgWFLaiSTLeungCYet al

This enhances the clinical relevance of research findings [203]

Conversely, methionine supplementation or exogenous activation of AMPK can restore H3K79me2 and AMPK levels, reduce PD-1 expression, and thereby enhance the anti-tumor immune response of CD4 + T cells