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Nature 491 , 384392

The single cells and the cell spheroids used in the experiments are first prepared by culturing cells in conventional monolayer and 3D spheroid formats as shown in Figure 1A

These mechanisms include interaction with the electron transport chain, through a pathway of oxidative phosphorylation, or blocking a nutrient uptake

A structural comparison of the wild-type AR bound to DHT and the agonist-converted AR-bicalutamide complex demonstrated that the sites that bind the A and B rings of DHT are similar to the sites bound by bicalutamide