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Role of phenolic compounds in human disease: current knowledge and future prospects

The genetic association between the genes encoding methionine synthase and N5,10-methylenetetrahydrofolate reductase suggests a close relationship between these enzymes and the tetrahydrofolate metabolism (Figure 2) [14, 15, 16, 17]

Further basic and translational research is needed to identify individuals more susceptible to ROS damage, and to clarify whether ROS is an important target to treat COPD and AATD patients

Rings with high aromaticity are stable systems with low reactivity and low susceptibility to substitution

The 3D structures of the homologous Mn and Fe superoxide dismutases have the same arrangement of alpha-helices, and their active sites contain the same type and arrangement of amino acid side-chains