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In the first one, we use in the three hybrid models the wild type A 42 sequence for both the L-peptides and the DRI peptides, while in the second case we replace the wild type DRI-peptides by the K28E mutant DRI-peptide

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With the new research development and advancements in technologies, the future proposed methods to combat biofilm-mediated antibiotic infections include the use of nanoparticles, antimicrobial peptides, photodynamic therapy and implementation of gene editing technologies like CRISPR/Cas9 ( Figure 2 )

6.2 Cancer treatment At the beginning of the 1950s, apitoxins influence on the colchicine-induced carcinogenic pathway was documented (Gajski et al., 2024)