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In parallel, targeted preclinical studies are needed to clarify how glutamine affects key molecular pathways underlying its observed effects

Zhang R, Xue B, Tao Y, Zhao H, Zhang Z, Wang X, Zhou X, Jiang B, Yang Z, Yan X, Fan K

These changes only to a small extent include the genes controlled by Nrf2

K i : 83.13 1.33 nM for compound 26 )

Ouabain, a natural compound belonging to the cardiac glycosides family, reduces cell survival through apoptotic pathway in human senescent cells induced by genotoxic stress (Etoposide, Doxorubicin and Palbociclib), OIS, or replicative exhaustion