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A postmortem study of suicidal bipolar, MDD, and schizophrenic patients provided intriguing insights into a possible role for microglia in the pathophysiology of these conditions

The peptide binds reversibly to G-actin (globular actin monomers) throughout the body, accumulating in tissues undergoing active remodeling or repair

doi: 10.3389/fneur.2018.01033 Received 26 August 2018 Accepted 16 November 2018 Published 10 January 2019 Volume 9 - 2018 Edited by Kenneth Joseph Friedman, Medical School, Rutgers, The State University of New Jersey, United States Reviewed by Dinesh Upadhya, Manipal Academy of Higher Education, India

On one hand, excess unstable -globin chains bind with heme to form haemichromes that are deposited in the erythroblasts membrane

The second mechanism requires scavenging protein hemopexin (Hx)