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Furthermore, the enzymatic activity of catalase increased significantly in the epididymal tissues, while, on the other hand, the activity of manganese superoxide dismutase (Mn SOD) and glutathione peroxidase (GPX) decreased in the seminal vesicle

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204,207 These results raise the possibility that RNAP II and mtRNAPs might function as both sensors and executors, which sense NAD + /NADH ratios and induce the NAD + capping to regulate the gene expression, leading to the crosstalk between cellular NAD + metabolism and transcriptional activity

Research has demonstrated a significant difference in the percentage of m6A-modified mRNAs between AD tissue samples and healthy aortas, indicating a distinct molecular landscape in the pathology of the disease