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A 2021 Nature Aging study by Lee and colleagues examined MOTS-c in the context of aging directly

Miller JW, Nadeau MR, Smith J, Smith D, and Selhub J (1994b)

[1] [6] Glutathione Injection exerts its effects primarily through the pharmacological actions of glutathione, a naturally occurring intracellular antioxidant

If these values have dropped to standard level it is only an indication that treatment is effective and should not be used to measure treatment efficacy (values are good, lets stop treatment)