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There is also an ASO in development for genetic ALS caused by a mitochondrial protein mutation (Table 9)

Globally, I believe [no current data to support this] that large doses of oral B12 have been used to some good effect, although it's not possible to work out who will benefit unless you do the experiment, and for that, if it meets the criteria of a clinical study, it needs [certainly in the UK] to be appropriately designed and reviewed before the work starts, and the results should be presented afterwards

Antioxidant Activity: It neutralizes free radicals, unstable molecules that can damage cells and accelerate aging, thus protecting tissues from oxidative stress

Gastrointestinal absorption of vitamin B 12 depends on the presence of sufficient intrinsic factor and calcium ions

The Cochrane database of systematic reviews , (12), CD007769