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Severe deficiency can cause deep depression, paranoia, delusions, incontinence, loss of taste and smell, and other neurological damage

They are not intended for diagnostic or therapeutic applications, and they should be handled only by qualified personnel in appropriately equipped laboratory environments using established institutional procedures for chemicals and laboratory reagents

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Evidence : Animal studies (e.g., ob/ob mice) showed up to 50% reduction in body fat without affecting blood sugar or appetite

Homocysteine, inflammation, and the brain When B12 is low, homocysteine accumulates