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32 To elucidate the mechanism by which ACE elevates Fe 2+ , we further determined whether ACE increased intracellular Fe 2+ by upregulating HO-1

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Dietary iron deficiency was suspected to be the cause of iron deficiency in foals (Brommer et al 2001, Fleming et al 2006)

the invention also provides methods of obtaining optimized immunomodulatory sequences that encode a cytokine antagonist