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Consistently, restricting GSH intake by feeding worms with DB failed to prolong the lifespan of nuo-6 animals to the same extent as the wt (Supplementary Fig

The research team identified that erastin could directly bind to VDAC2/3, leading to loss of mitochondrial function as well as the emission of substantial amounts of oxides, finally causing ferroptosis (Yagoda et al., 2007)

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Combined depletion of ASCT2 with a serine-free diet induces tumor regression (27)