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UV radiation can excite skin cells, resulting in the generation of ROS such as singlet oxygen (1O2) and superoxide radicals [53]

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However, free Cys, small thiols, and most Cys in proteins react quite poorly with H 2 O 2 , with rate constants of the order of 10 M 1 s 1 [1], indicating that their oxidation cannot be accomplished during rapid physiological peroxide fluctuations

The findings not only deepen our understanding of PCOS pathogenesis but also establish a strong theoretical foundation for innovative microbiome-based therapeutics

160,161 For example, HM15211, a triple agonist developed by Hanmi Pharmaceutical in South Korea that activates GLP-1R, GIPR and GCGR has entered early clinical trials for the treatment of obesity and non-alcoholic steatohepatitis (NASH)