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In neuroendocrine prostate tumors, loss of tumor suppressor protein kinase C (PKC) / enhanced serine metabolism through mTORC1/ATF4/PHGDH axis, which leads to aberrant DNA methylation by increased one-carbon metabolic flux, ultimately leading to treatment resistance and poor prognosis [98]

Levkovitz, Y., Avignone, E., Groner, Y., & Segal, M

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The functional importance of FAs is reflected by the fact that their components are linked to diseases including osteoporosis 5 , cardiovascular disease, muscular dystrophy 1 and cancer

Cui P, Tang Z, Zhan Q, Deng C, Lai Y, Zhu F, et al