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PLoS ONE 7 (7), e40417-

TABLE 2 The regression equation, linear range, r 2 , and LLOQ of six analytes in plasma and brain tissue (n = 6)

Budesonide has 90% first-pass hepatic metabolism, and therefore has less systemic absorption beyond the intestinal tract and the liver, reducing the risk of glucocorticoid toxicity with high doses or long-term use