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To cope with the elevated oxidative stress they generate, cancer cells enhance their antioxidant capacity, largely through sustained activation of the transcription factor NRF2 often driven by mutations in its negative regulator KEAP1

A rare but clinically significant manifestation is pseudo-thrombotic microangiopathy (PTMA), which closely resembles true thrombotic thrombocytopenic purpura (TTP), characterized by hemolytic anemia, thrombocytopenia, the presence of schistocytes, and elevated lactate dehydrogenase (LDH) levels [2]

doi: 10.1007/bf01963567 15 GerverWJDe BruinRDelemarre v d WaalHAAldewereldBTheunissenPet al

& Gomes, I