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The spatial arrangement of hepatocytes along the flow from the portal tract of the central vein ensures that bilirubin metabolism further emphasizes the intercellular transfer of bilirubin and its metabolites, maintaining overall homeostasis [28]

Hexokinase 2 (HK2), which catalyzes the first step of glycolysis, is stabilized by the deubiquitinase CSN5 in HCC, promoting metastasis

doi: 10.1093/jn/nxz029 159 PilankarASinghaviHRaghuramGVSiddiquiSKhareNKJadhavVet al

By reducing these oxidative species, they indirectly regulate S-glutathionylation by preventing excessive oxidative stress, which is a trigger for S-glutathionylation

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