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The hydrogel eye mask patch provides a cooling effect upon application, reducing skin temperature while promoting absorption of active ingredients deep into the skin

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Further, the inherent limitations of studying topical dosing in murine models necessitates further studies of pharmacokinetics and efficacy in larger species, as well as ocular safety and tolerability studies

Furthermore, considering the significant role that mitochondrial function and biogenesis play in long-term aerobic adaptation and exercise performance and the involvement of NO in these pathways, our understanding of NO and the application of nitrate supplementation would greatly benefit from continued investigation within these topics

This is the safest point to begin to assess tolerance and minimize the risk of side effects