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This paper aims to explore the main bioactive metabolites of PPE and its applications in biomedicine (Figure 1), while providing an in-depth analysis of its limitations in practical applications and its development potential

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Its anti-inflammatory effects may also improve blood flow and vascular function in peripheral artery disease or diabetic vasculopathy

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Such studies could advance our understanding of the molecular mechanisms underlying GR homeostasis dysregulation in various pregnancy disorders and lead to novel strategies to prevent or reverse these molecular changes, ultimately paving the way for optimized perinatal glucocorticoid therapies in the era of precision medicine