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Although ERK activation is generally associated with pro-survival signaling, it occurs alongside impaired apoptotic and transcriptional responses in SCA3, creating an imbalance that undermines neuronal fate determination

Pediatr Pulm 1994;10:275.Google Scholar Loverdos, I, Gonska, T, Ling, SC

Prestifilippo et al., Acute effect of manganese on hypothalamic luteinizing hormone releasing hormone secretion in adult male rats: Involvement of specific neurotransmitter systems, Toxicol

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The authors underlined that this could be mediated by the reduction in caspase-3/7 activity, by the increase in the B-cell lymphoma 2/BCL-2-like protein 4 (BCL2/BAX) ratio and by the reduction in tumor protein 53 (TP53), caspase-3 (CASP3) and caspase-8 (CASP8) expression [82]