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Key Takeaway: Glutathione is a naturally occurring tripeptide that protects cells from oxidative stress and is most concentrated in the liver, where it facilitates detoxification

Evidence from other neurodegenerative and vascular disorders shows that pericyte loss destabilizes the BBB, microglial activation induces astrocyte reactivity, and endothelial heterogeneity influences barrier resilience ( Translational gaps and human relevance A significant translational gap remains between preclinical discoveries and human pathology

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Specific considerations must be taken for infants and daughters, such as the direct exposure of a developing fetus from a mother who has been exposed, ingestion through breast milk, and exposure during hospitalization through direct injection into the bloodstream via medical tubing or intravenous (IV) procedures [99]