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Moreover, despite their biomimetic architectural excellence, these systems inevitably constitute simplified approximations of the extraordinarily complex in vivo physiological milieu, potentially obscuring critical intercellular communication networks, systemic immunological responses, and multi-organ interaction paradigms that characterize authentic pathophysiological processes

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Moreover, microsomal metabolism studies demonstrated that Dihexa had very low phase I metabolism, with an average intrinsic clearance of 2.72 l/min/mg and a half-life of 509.4 minutes

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Concurrently, M1 macrophages possess the ability to activate NK T cells to secrete IFN-, thus accelerating the development of early-stage atherosclerosis (134)