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Initial high-throughput compound screening and further medicinal chemistry-based optimization developed two novel series of phenylurea-based compounds inhibiting GOT1 enzymatic activity with potencies in the low micromolar IC 50 range 155

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Figure 2 Table 2 Change characteristics of the main microbial communities in the feces of the GAS diet group

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( Cited in the Washington Times, March 2012 )

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Targeting ferroptosis: Paving new roads for drug design and discovery

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For extinct glacial animals, refer to relevant ancient DNA research literature to obtain validated sequence data

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