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Early studies show that PRP may be effective in the treatment of rotator cuff tears, but more research is needed to establish its long-term safety and efficacy

Yang N, Zhu S, Lv X, Qiao Y, Liu YJ, Chen J

Vitamin B12 injections are generally safe but can cause complications and adverse effects in some cases

Ozone helps increase high-density lipoprotein (it has an anti-inflammatory action), and reduces some inflammatory compounds, such as C-reactive protein, total cholesterol, low-density lipoprotein, triglycerides, and homocysteine. An additional effect of the therapy may be a regulation of the autonomic nervous system in complex regional pain disorders. Presenters at multiple ozone conferences have reported improvement in both local and diffuse pain disorders with simple intravenous ozone applications