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Many treatment strategies aiming to directly disrupt the formation of amyloid (A) plaques and neurofibrillary tangles (NFTs), the two major AD hallmarks, showed modest or no benefit [2]

Gadde KM, Martin CK, Berthoud HR, et al

[3] The niacin supplement-only trial did not find a reduction in CVD events and also noted a significant increase in adverse reactions compared with the placebo group, including increased incidence of type 2 diabetes, gastrointestinal bleeding and ulcers, and diarrhea

Studies with isolated hepatocytes would establish that human cells are less sensitive than those from mice, and that this difference is due to the relative rates of NAPQI formation

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