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While studies attempting to localize the pathology in FMS to peripheral tissues have failed in showing any abnormalities in muscle tissue, Staud and coworkers did show that enhanced central pain processing can occur via continued peripheral muscle afferent input, Their study demonstrated that muscle lidocaine injections increased local pain thresholds and decreased remote secondary heat hyperalgesia in fibromyalgia patients, emphasizing the important role of peripheral impulse input in maintaining central sensitization

Diabetes 52 : 24832489 Mauras N et al

Sermorelin supports recovery indirectly through increased GH and IGF-1, which promote tissue repair, protein synthesis, and cellular regeneration

Brand-name semaglutide costs $1,000 to $1,600 per month without insurance, while compounded semaglutide ranges from $150 to $500 per month

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