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Biology (basel) 9:131

When an infected cell is found these natural killer cells and cytotoxic T cells either send a message through a receptor-ligand interaction that instructs the cell to self-destruct, or they create a pore in the cell to transfer lethal enzymes into the infected cell to kill it

However, during inflammatory reactions, exposure of macrophages to interferon (IFN) and TNF results in the activation of the inducible isoenzyme of NOS (iNOS), which increases up to 10 times the levels of nitric oxide