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Bacteria have the ability to alter their DNA when under hostile conditions such as nutrient unavailability, exposure to toxins, or stress, to become more resistant to treatment ( Community-level resistance also leads to treatment failure in periodontal infection

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The treatment included injections of B12 and within a period of two years, the patient had no symptoms

Conclusion: We have established a set of ex vivo assays to assess the binding and uptake efficiency of GalNAc conjugates in primary hepatocytes from various species, as well as HepG2 cells