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To further confirm the inhibitory effect of GDF11 on cell apoptosis, we detected the expression of genes and proteins in the GDF11 and control groups by Western blotting and qPCR, and the results showed that Bcl2 expression was significantly higher in the GDF11 group than in the control group (Figures 2C,F,G), whereas Bax and caspase3 expression was significantly decreased (Figures 2DF,H,I)

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Retatrutide and cagrilintide are both investigational drugs not approved by the FDA

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Vitamin D/vitamin D receptor (VDR) signaling intersects inflammation, oxidative stress/mitochondrial injury, fibrogenic pathways, the reninangiotensinaldosterone system (RAAS), and the gutkidney axis, providing a biologic rationale for renoprotection