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Hydrogen peroxide- and glutathione-associated mechanisms of acclimatory stress tolerance and signaling

A retrospective study looking at concomitant use of proton pump inhibitors (PPIs) alongside metformin in 614 people with type 2 diabetes in the US found a significant reduction in B12 levels of 34% in patients taking both medications, compared to controls taking either drug alone (Long et al, 2012)

*Clinical response=reduction in complete Mayo score of 3 points and 30% from baseline with an accompanying decrease in rectal bleeding subscore of 1 point or absolute rectal bleeding subscore of 1 point

COX-2 and PGs cause uterine contractions and can therefore induce miscarriage or preterm birth ( Moreover, COX-2 regulates severe malarial anemia (SMA)

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