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Following the application of BM-MSCs, the researchers demonstrated protective effects of BM-MSCs secretome, maintaining TH + dopaminergic neurons in hMOs exposed to 6-OHDA

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Phospholipid peroxy radicals are relatively unstable and can react with Fe 2+ , resulting in a chain expansion of phospholipid peroxidation, thus triggering ferroptosis signals ( 3.4 Transcription factors and ferroptosis P53 and Nrf2, as widely reported transcription factors, participate in the metabolism of iron and reactive oxygen species by regulating SLC7A11, arachidonate 12-lipoxygenase (ALOX12) gene, NOQ1, HO-1, heme type I fluorosynthase and the frontotemporal hairline (FTHL) gene ( 4 The relationship between ferroptosis and ovarian diseases 4.1 Ovarian aging Ovarian aging is the process of gradual decline of ovarian function

Treatment should always be based on clinical need rather than perceived benefit