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The role of Ido1 and tryptophan metabolism, together with arginine metabolizing enzymes, has been extensively studied in the context of metabolic reprogramming of immune cells for balancing immunoregulatory and pro-inflammatory phenotypes 157,158,159 , thus being critical to wound healing, neoplasia, autoimmunity and the rejection of transplanted tissues 155,160,161,162

The advantage of this type of compounds, apart from the reduction in side effects, is their efcient metabolism to non-toxic products and a high afnity for specic molecular targets, which can potentially be associated with enhanced treatment efcacy, enabling the use of a relatively low dose to produce identical biological effects [ 3 ]

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The study of these distinct populations provides valuable insights into evolutionary processes, as well as metabolic and molecular adaptations to extreme environments