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Multi-region profiling of primary-metastatic prostate cancer pairs revealed in one case that metastases and the primary tumour were highly unrelated, suggestive of early divergence followed by parallel evolution, while, in another case, the metastatic subclone was found in the primary tumour but had accumulated additional mutations

Regulation of ubiquitin-binding proteins by monoubiquitination

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The finding shifted understanding of how mitochondria communicate beyond energy production, signaling through circulating peptides that reach distant tissues