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(ii) down-regulation of K + buffering resulting a neuronal hyper-excitability that disturbs circuit function and increases excitotoxic potential 128

Previous studies have shown that minoxidil increases the expression of genes related to hair growth-promoting factors such as FGF7 35 , while oxytocin and oxytocin receptor agonists increase VCAN and LEF1 expression 24,26

The needle can be inserted at a 90-degree angle (straight in, somewhat like a dart) or at a 45-degree angle

The bacterial taxa of the gut associated with PD development are discussed with emphasis on the enteric nervous system (ENS), as well as the impact of gut bacteria on dopamine production and levodopa metabolism