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Thus, whether TMAO is an atherogenic factor responsible for the development and progression of cardiovascular disease, or simply a marker of an underlined pathology, remains unclear [85]

doi:10.3389/fimmu.2021.785717

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Similarly, long-term treatment with the carnitine inhibitor meldonium can induce adaptive cardioprotective effects by altering energy metabolic pathways [299]

Interestingly, -oxidation and aerobic glycolysis are connected to each other through cross-signaling in such a manner that beta-oxidation not only is compatible with ongoing aerobic glycolysis, but also it promotes the Warburg Effect