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In line with the covalent binding mechanism, in vitro and cell-based thermal-shift assays showed that C1-27 induced a negative shift in the melting temperature indicating protein destabilization on binding (Supplementary Figs 11 and 15)

Int J Mol Sci 21:21:5657

The gut microbiota contributes to host metabolism and protects against pathogens, thereby affecting directly or indirectly host physiological functions ( Collinsella belongs to the family Coriobacteriaceae and the phylum Actinobacteria

10.1111/ppl.12032 [Epub ahead of print]

Other reports of mild side effects include lack of appetite, constipation, nausea, dry mouth, sweating, and anxiety/nervousness, but in placebo-controlled studies, these side effects occur at about the same incidence in the placebo groups