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In ischemia/reperfusion injured rat intestine, an infusion of intravenous trimetazidine (3 mg/kg) lowered malondialdehyde and myeloperoxidase, which is a pro-oxidative enzyme that catalyzes the formation of ROS [177]

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Enzymatic Antioxidants Several enzymes obstruct free radicals formation, some of them act directly in scavenging ROS (primary enzymes), whereas secondary enzymes play an indirect role by supporting other endogenous antioxidants (Figure 2)